Maalox plus 30 chewable tablets

Maalox Plus 30 Chewable Tablets is a medicine indicated for the symptomatic treatment of heartburn or stomach pain, due to hyperacidity and gastroesophageal reflux.

Maalox Plus decreases the amount of acid in the stomach and excess intestinal gas. Maalox Plus is also indicated for the treatment of gastroduodenal ulcers .

Posology and method of use of Maalox plus 30 chewable tablets

How to take Maalox Plus 200mg + 200mg + 25mg 30 tablets ?

Dosage: 2 – 4 tablets of Malox Plus 4 times a day, 20–60 minutes after meals and before going to bed.

The tablets must be chewed or sucked well . Their intake can be followed by ingestion of water or milk. Pediatric population The administration of the medicinal product in children is not recommended.

Active ingredients and excipients Maalox plus 30 chewable tablets

Active ingredients: magnesium hydroxide 200 mg aluminum oxide, hydrate 200 mg dimethicone 25 mg Excipient(s) with known effect: glucose, sucrose, sorbitol. For the complete list of excipients.

Excipients: Maize starch, citric acid, pregelatinised starch, glucose, mannitol, sucrose, sorbitol, non-crystallizable liquid sorbitol, talc, magnesium stearate, saccharin sodium, lemon flavour, Swiss cream flavour, E 172.

Contraindications Maalox plus 30 chewable tablets

Maalox Plus 200 mg + 200 mg + 25 mg is contraindicated in case of:

• Hypersensitivity to the active substances or to any of the excipients
• Patients with porphyria.
• Severe forms of renal insufficiency (creatinine clearance less than 30 mL/min).
• Generally contraindicated in children.
• state of cachexia.

Side effects Maalox plus 30 chewable tablets

Side effects of Maalox Plus 200mg + 200mg + 25mg.

• Immune system disorders: Frequency not known (frequency cannot be estimated from the available data): angioedema, anaphylactic reactions, hypersensitivity reactions, urticaria, pruritus.
• Gastrointestinal disorders: diarrhea or constipation.
• Metabolism and nutrition disorders: Frequency not known (frequency cannot be estimated from the available data): hypermagnesaemia, hyperaluminaemia, hypophosphataemia, during prolonged use or at high doses or even at normal doses of the medicinal product in patients with low in phosphorus or in children (0 to 24 months), which can cause increased bone resorption, hypercalciuria, osteomalacia.

Warnings Maalox plus 30 chewable tablets

Aluminum hydroxide can cause constipation and an overdose of magnesium salts can cause hypomotility of the intestine; high doses of this medicinal product may cause or aggravate intestinal obstruction and ileus in patients at higher risk, such as those with renal impairment, underlying constipation, impaired intestinal motility, infants (0 to 24 months) , or elderly.

Aluminum hydroxide is not well absorbed from the gastrointestinal tract, and systemic effects are therefore rare in patients with normal renal function. However, excessive doses or long-term use, or even normal doses in patients on low phosphorus diets or in children (0 to 24 months), may lead to phosphate elimination (due to aluminium-phosphate bonding) accompanied by an increase in bone resorption and hypercalciuria with risk of osteomalacia. It is advisable to consult your doctor in case of long-term use or in patients at risk of hypophosphataemia.

In patients with renal impairment, the plasma levels of aluminum and magnesium tend to increase, causing hyperaluminemia and hypermagnesaemia, respectively. In these patients, long-term exposure to high doses of aluminum and magnesium salts may lead to encephalopathy, dementia, microcytic anemia, or worsening of dialysis-induced osteomalacia. In the presence of mild and moderate forms of renal insufficiency, it is recommended to take the product under the supervision of a doctor. Prolonged use of the medicinal product should be avoided in these patients. Prolonged use of the medicinal product should be avoided in these patients. Aluminum hydroxide may be unsafe in patients with porphyria undergoing hemodialysis. Maalox Plus, due to its composition, has no tendency to modify the behavior of the hive. However, in some particularly sensitive subjects and for high doses, it is possible to experience an acceleration of intestinal transit.

Maalox Plus 200 mg + 200 mg + 25 mg chewable tablets contain sorbitol, sucrose and glucose: patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine . This medicinal product contains 0.5 g of glucose per dose. To be taken into consideration in people with diabetes mellitus.



Interactions Maalox Plus tablets and other drugs
Since Al and Mg salts reduce the gastrointestinal absorption of tetracyclines, it is recommended to avoid taking Maalox Plus during oral tetracycline therapy. The use of aluminum-containing antacids may reduce the absorption of drugs such as H2-antagonists, atenolol, cefdinir, cefpodoxime, chloroquine, tetracyclines, diflunisal, digoxin, bisphosphonates, ethambutol, fluoroquinolones, sodium fluoride, glucocorticoids, indomethacin, isoniazid, ketoconazole, levothyroxine, lincosamides, metoprolol, phenothiazine neuroleptics, penicillamines, propranolol, rosuvastatin, iron salts.

Polystyrene sulphonate (Kayexalate) Caution is advised when the medicinal product is taken together with polystyrene sulphonate (Kayexalate) due to the potential risk of reduced efficacy of the resin in binding potassium, metabolic alkalosis in patients with renal impairment (reported with aluminum hydroxide and magnesium hydroxide), and intestinal obstruction (reported with aluminum hydroxide).

Aluminum hydroxide and citrates can cause hyperaluminaemia, especially in patients with renal impairment.

Leave at least two hours (4 for fluoroquinolones) before taking Maalox Plus to avoid interaction with other drugs. Concomitant use of quinidine may lead to increased serum quinidine levels and lead to quinidine overdose. The simultaneous use of aluminum hydroxide and citrates can lead to an increase in aluminum levels, particularly in patients with renal insufficiency.

Overdose Maalox Plus tablets
Experience with deliberate overdose is very limited. Cases of overdose with aluminum salts can occur more easily in patients with chronic severe renal impairment with the following symptoms: encephalopathy, convulsions and dementia, hypermagnesaemia. The most frequently reported symptoms of acute overdose with aluminum hydroxide and in combination with magnesium salts include diarrhoea, abdominal pain and vomiting. High doses of this medicinal product may cause or aggravate intestinal obstruction and ileus in patients at risk.

As in all cases of overdose, treatment should be symptomatic, adopting general supportive measures. Aluminum and magnesium are eliminated through urinary excretion; the treatment of magnesium overdose involves rehydration and forced diuresis. In case of renal insufficiency, hemodialysis or peritoneal dialysis is required.

Pregnancy and breastfeeding Maalox plus 30 chewable tablets

Can I take Maalox Plus tablets when pregnant or breastfeeding?

Pregnancy The medicinal product should only be used if necessary, under the direct supervision of a doctor, after evaluating the expected benefit for the mother in relation to the possible risk for the fetus or infant. Lactation Due to limited maternal absorption when taken according to the indicated dosage regimen, aluminum hydroxide and its combinations with magnesium salts are considered compatible with lactation.

Expiration and conservation of Maalox plus 30 chewable tablets

How to store Maalox Plus 200mg + 200mg + 25mg 30 tablets?

Chewable tablets: store below 25°C.