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Aspirin C 20 Effervescent Tablets 400+240 mg

Aspirin C 20 Effervescent Tablets 400+240 mg

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Aspirin C Effervescent tablets with vitamin C is a treatment for the symptoms of fever , flu and cold syndromes based on acetylsalicylic acid . Aspirin C Tablets has an effective antipyretic and analgesic action . Indicated for the symptomatic treatment of headaches, toothaches, neuralgia, menstrual pain, rheumatic and muscular pain.

Dosage and posology Aspirin C 20 Effervescent Tablets 400+240 mg

The Aspirin C 400 mg Effervescent Tablets should be dissolved (one tablet in half a glass of water) and taken in a dose of 1-2 tablets as a single dose , repeating, if necessary, the dose at intervals of 4-8 hours up to 3- 4 times a day. Take the medicine preferably after main meals or, in any case, on a full stomach. The use of Aspirin C effervescent tablets is reserved for adult patients only . Always use the minimum effective dosage and increase it only if it is not sufficient to relieve symptoms (pain and fever).

Do not exceed the recommended dose. Use the medicine for the shortest period possible. Do not take the product for more than 3 – 5 days without medical advice.
Consult your doctor if symptoms persist.

Composition Aspirin C 20 Effervescent Tablets 400+240 mg

Aspirin C 400 mg Effervescent Tablets contains for each tablet:

  • Active ingredients: Acetylsalicylic acid 0.4 g, ascorbic acid (Vitamin C) 0.240 g.
  • Excipients : Monosodium citrate, sodium bicarbonate, sodium carbonate, anhydrous citric acid.

Warnings Aspirin C 20 Effervescent Tablets 400+240 mg

In case of accidental ingestion of an excessive dose of Aspirin 400 mg effervescent tablets with vitamin C, notify your doctor immediately or go to the nearest hospital. Salicylate toxicity (a dosage greater than 100 mg/kg/day for 2 consecutive days can induce toxicity) can be the consequence of a chronic intake of excessive doses or of acute overdose, potentially life-threatening and which also includes l accidental ingestion in children.

Aspirin C 400 mg Effervescent Tablets is contraindicated in case of:

  • Hypersensitivity to the active substance (acetylsalicylic acid), to other analgesics (painkillers) / antipyretics (antipyretics) / non-steroidal anti-inflammatory drugs (NSAIDs) or to any of the excipients
  • Gastroduodenal ulcer;
  • Hemorrhagic diathesis;
  • Severe kidney, heart or liver failure;
  • Glucose –6-phosphate dehydrogenase deficiency (G6PD/favism);
  • Concomitant treatment with methotrexate (at doses of 15 mg/week or more) or warfarin;
  • History of asthma induced by the administration of salicylates or substances with similar activity, in particular non-steroidal anti-inflammatory drugs;
  • Third trimester of pregnancy and breastfeeding;
  • Children and young people under the age of 16.

Aspirin C 20 effervescent tablets can cause side effects, although not everybody gets them. The most frequently observed side effects affect the gastrointestinal system. These disorders can be partially alleviated by taking the medicine on a full stomach. Most side effects are dependent on both the dose and duration of treatment. The side effects observed with acetylsalicylic acid are generally common to other NSAIDs.

Hypersensitivity reactions
Acetylsalicylic acid and other NSAIDs may cause hypersensitivity reactions (including asthma attacks, rhinitis, angioedema or urticaria). The risk is greater in subjects who have already had a hypersensitivity reaction in the past after the use of this type of drug and in subjects who have allergic reactions to other substances (e.g. skin reactions, itching, hives).
In subjects with asthma and/or rhinitis (with or without nasal polyposis) and/or urticaria the reactions may be more frequent and serious. In rare cases, reactions can be very serious and potentially fatal.

In the following cases, administration of the drug requires a doctor's prescription after careful evaluation of the risk/benefit ratio:

  • Subjects at increased risk of hypersensitivity reactions
  • Subjects at increased risk of gastrointestinal lesions

Acetylsalicylic acid and other NSAIDs can cause serious side effects at the gastrointestinal level (bleeding, ulcer, perforation). For this reason these drugs should not be used by subjects suffering from gastrointestinal ulcers or gastrointestinal bleeding. It is also prudent for those who have suffered from gastrointestinal ulcers or gastrointestinal bleeding in the past to avoid its use. The risk of gastrointestinal lesions is a dose-related effect, as gastrointestinal lesions are greater in subjects who use higher doses of acetylsalicylic acid. Even subjects with a habit of drinking large quantities of alcohol are more exposed to the risk of gastrointestinal lesions (bleeding in particular).

Subjects with coagulation defects or being treated with anticoagulants
In subjects suffering from coagulation defects or being treated with anticoagulants, acetylsalicylic acid and other NSAIDs can cause a serious reduction in haemostatic capacity, exposing them to the risk of haemorrhage.

Subjects with impaired renal, cardiac or hepatic function
Acetylsalicylic acid and other NSAIDs can cause a critical reduction in renal function and water retention; the risk is greater in subjects treated with diuretics. This can be especially dangerous for the elderly and for those with impaired kidney, heart or liver function.

Subjects suffering from Asthma
Acetylsalicylic acid and other NSAIDs can cause an aggravation of asthma.

Geriatric age (especially above 75 years)
The risk of serious side effects is greater in geriatric subjects. Subjects over the age of 70, especially in the presence of concomitant therapies, should use Aspirin C effervescent tablets only after consulting their doctor. Aspirin C should not be used in children and young people under 16 years of age.

Subjects with hyperuricemia/gout
Acetylsalicylic acid can interfere with the elimination of uric acid: high doses have a uricosuric effect while (very) low doses can reduce its excretion. It should also be considered that acetylsalicylic acid and other NSAIDs can mask the symptoms of gout, delaying its diagnosis. An antagonistic effect with uricosuric drugs is also possible.

Combination of drugs not recommended or requiring special precautions or dosage adjustment.
The use of acetylsalicylic acid in combination with some drugs may increase the risk of serious side effects. Do not use acetylsalicylic acid together with another NSAID or, in any case, do not use more than one NSAID at a time.

The use of acetylsalicylic acid as well as any drug that inhibits the synthesis of prostaglandins and cyclooxygenase could interfere with fertility; female subjects and in particular women who have fertility problems or who are undergoing fertility investigations must be informed of this.

This medicinal product contains sodium: it may not be suitable for people on a low-sodium diet, consult your doctor. If you have to undergo surgery (even a small one, for example the extraction of a tooth) and in the previous days you have used acetylsalicylic acid or another NSAID, you must inform the surgeon due to the possible effects on coagulation .

Since acetylsalicylic acid can cause gastrointestinal bleeding, this must be taken into account if it is necessary to carry out a search for occult blood. Before administering any medicine, all necessary precautions must be taken to prevent unwanted reactions; particularly important is the exclusion of previous hypersensitivity reactions to this or other medicines and the exclusion of other contraindications or conditions that may expose you to the risk of potentially serious side effects listed above.

Aspirin C 20 Effervescent Tablets 400+240 mg during Pregnancy and Breastfeeding

Acetylsalicylic acid is contraindicated during the third trimester of pregnancy
Inhibition of prostaglandin synthesis can negatively affect pregnancy and/or embryo/foetal development. Results of epidemiological studies suggest an increased risk of miscarriage and cardiac malformation and gastroschisis after the use of a prostaglandin synthesis inhibitor in the early stages of pregnancy. The absolute risk of cardiac malformations was increased from less than 1% to approximately 1.5%. It has been estimated that the risk increases with the dose and duration of therapy.
In animals, the administration of prostaglandin synthesis inhibitors has been shown to cause an increase in pre- and post-implantation loss and embryo-foetal mortality. Furthermore, an increased incidence of various malformations, including cardiovascular malformations, has been reported in animals administered prostaglandin synthesis inhibitors during the organogenetic period.

During the first and second trimester of pregnancy, acetylsalicylic acid should not be administered unless clearly necessary. If drugs containing acetylsalicylic acid are used by a woman trying to become pregnant, or during the first and second trimester of pregnancy, treatment should be as short as possible and the dose as low as possible. During the third trimester of pregnancy, all inhibitors of prostaglandin synthesis can expose the fetus to: cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension); renal dysfunction, which may progress to renal failure with oligohydroamnios; The use of Aspirin C Effervescent Tablets can expose the mother and the unborn child, at the end of pregnancy, to: possible prolongation of bleeding time, an anti-aggregating effect which can occur even at very low doses; inhibition of uterine contractions resulting in delayed or prolonged labor.

Consequently, acetylsalicylic acid is contraindicated during the third trimester of pregnancy

Feeding time
Aspirin C 400 mg Effervescent Tablets is contraindicated during breastfeeding.

Expiration and storage Aspirin C 20 Effervescent Tablets 400+240 mg

The expiry date refers to the product in intact packaging, correctly stored. Keep the medicine out of the reach and sight of children. Store at a temperature below 30°C. Do not use the medicine after the expiry date indicated on the package.

Imperfect and prolonged storage of Aspirin C can cause variations in the color of the tablet which in themselves do not affect either the activity or tolerability of the active ingredient. In this case, it is still advisable to ask the pharmacy for the packaging to be replaced.
If in doubt, consult your doctor or pharmacist. The product must be taken on a full stomach.



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