{"product_id":"zerinolflu-20-compresse-effervescenti","title":"ZerinolFlu 20 effervescent tablets","description":"\u003cp\u003e\u003cstrong\u003eINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTreatment of flu and cold symptoms in adults.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eZerinolflu is contraindicated in the following cases: - hypersensitivity to paracetamol, chlorphenamine or ascorbic acid, to any of the excipients listed in paragraph 6.1 or to other substances closely related from a chemical point of view, in particular antihistamines with a chemical structure similar to chlorphenamine; - pregnancy and breastfeeding; - patients with manifest insufficiency of glucose-6-phosphate dehydrogenase and patients suffering from severe hemolytic anemia; - severe hepatocellular insufficiency (Child-Pugh C); - glaucoma, prostatic hypertrophy, bladder neck obstruction, pyloric and duodenal stenosis or other tracts of the gastrointestinal and urogenital system, due to anticholinergic effects; - patients being treated with monoamine oxidase inhibitors (MAOIs) or in the two weeks following such treatment (see section 4.5).\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWARNINGS AND PRECAUTIONS FOR USE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDo not administer for more than 3 consecutive days without consulting your doctor. If the fever persists for more than three days or if the symptoms do not improve and others appear within three days or are accompanied by high fever, rash, excessive amount of mucus and persistent cough, consult your doctor before continuing the administration. \u003cu\u003eParacetamol\u003c\/u\u003e During treatment with Zerinolflu, check that no other medicine containing paracetamol is taken at the same time, since if paracetamol is taken in high doses, serious adverse reactions may occur. Invite the patient to contact the doctor before combining any other drug. See also paragraph 4.5. High or prolonged doses of the product can cause high-risk liver disease (see also section 4.9) and even serious alterations in the kidney and blood. In case of acute hypersensitivity reactions to paracetamol (e.g. anaphylactic shock), treatment with Zerinolflu should be discontinued and necessary medical measures should be implemented based on the signs and symptoms. \u003cu\u003eChlorphenamine maleate\u003c\/u\u003e At common therapeutic doses, antihistamines present secondary reactions that vary greatly from subject to subject and from compound to compound. The most frequent side effect is sedation which can manifest itself with drowsiness; Those who may drive motor vehicles or carry out operations that require integrity of the level of supervision must be warned of this (see paragraph 4.7). \u003cu\u003eAscorbic acid\u003c\/u\u003e Ascorbic acid (vitamin C) should be used with caution by subjects who suffer, or have suffered in the past, from nephrolithiasis (kidney stones) and by those suffering from G6PD (Glucose-6-phosphate dehydrogenase) deficiency, hemochromatosis, thalassemia or sideroblastic anemia. \u003cu\u003ePatients with renal or hepatic insufficiency\u003c\/u\u003e Administer with caution in subjects with renal or hepatic insufficiency. \u003cu\u003eElderly\u003c\/u\u003e Particular attention should be paid when determining the dose in the elderly due to their greater sensitivity towards the drug. In elderly patients treated with antihistamines, effects such as dizziness, sedation, confusion and hypotension may be more likely to occur. Elderly patients are particularly sensitive to the anticholinergic side effects of antihistamines such as dry mouth and urinary retention (especially in men). \u003cu\u003eZerinolflu effervescent tablets contains\u003c\/u\u003e: \u003cu\u003eAspartame\u003c\/u\u003e This medicine contains a source of phenylalanine. It can be harmful if affected by phenylketonuria (lack of the enzyme phenylalanine hydroxylase). \u003cu\u003eSorbitol\u003c\/u\u003e Patients with rare hereditary problems of fructose intolerance should not take this medicine. \u003cu\u003eSodium\u003c\/u\u003e One effervescent tablet contains 14.83 mmol sodium. To be taken into consideration in patients with reduced renal function or who follow a low sodium diet.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eINTERACTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eParacetamol\u003c\/u\u003e Use with extreme caution and under strict control during chronic treatment with drugs that can cause the induction of hepatic monooxygenases or in case of exposure to substances that can have this effect (for example rifampicin, cimetidine, antiepileptics such as glutetimide, phenobarbital, carbamazepine). Normally harmless doses of acetaminophen can cause liver damage if taken together with these drugs. The same applies to potentially hepatotoxic substances and in case of alcohol abuse. Habitual ingestion of anticonvulsant drugs or oral contraceptives can, through an enzymatic induction mechanism, accelerate the metabolism of paracetamol. The use of the product is not recommended if the patient is being treated with anti-inflammatories. Taking probenecid inhibits the binding of paracetamol to glucuronic acid, thereby reducing the clearance of paracetamol by a factor of approximately 2. Therefore, the dose of paracetamol should be reduced if administered in combination with probenecid. Cholestyramine reduces the absorption of paracetamol if administered within 1 hour of taking paracetamol. It is not yet possible to establish the clinical relevance of the interactions between paracetamol and oral anticoagulants. Therefore, prolonged use of paracetamol in patients being treated with oral anticoagulants is advisable only under medical supervision. Combining acetaminophen with chloramphenicol may prolong the half-life of chloramphenicol, increasing the risk of toxicity. The concomitant use of paracetamol and zidovudine increases the tendency of the latter to reduce the number of leukocytes (neutropenia). Therefore, you should take Zerinolflu together with zidovudine only under your doctor's supervision. Medicines that slow gastric emptying, such as propantheline, reduce the speed of absorption of paracetamol and delay the onset of its effect. However, medicines that accelerate gastric emptying, such as metoclopramide, lead to an increase in the speed of absorption. \u003cu\u003eInterference with laboratory tests\u003c\/u\u003e The administration of paracetamol can interfere with the determination of uric acid (using the phosphotungstic acid method) and with that of blood sugar (using the glucose-oxidase-peroxidase method). \u003cu\u003eChlorphenamine maleate\u003c\/u\u003e Other substances with anticholinergic action should not be taken at the same time as Zerinolflu, as these can cause significant interactions. The product is contraindicated in patients being treated with monoamine oxidase inhibitors (MAOIs) or in the two weeks following such treatment (see section 4.3) as these may prolong and intensify the anticholinergic and central nervous system (CNS) depressant effects of chlorphenamine maleate. The product may interact with alcohol, tricyclic antidepressants, neuroleptics or other drugs with a depressant action on the central nervous system such as barbiturates, sedatives, tranquilizers, hypnotics. These products should not be taken during therapy with Zerinolflu as they can cause an increase in the sedative effect. Like all preparations containing antihistamines, Zerinolflu can mask the first signs of ototoxicity of certain antibiotics. Chlorphenamine inhibits the metabolism of phenytoin and may cause phenytoin toxicity. \u003cu\u003eAscorbic acid\u003c\/u\u003e Ascorbic acid (vitamin C) reduces amphetamine levels by inhibiting gastrointestinal absorption. Vitamin C increases the bioavailability of iron by chelation with deferoxamine. Estrogens can increase the elimination of vitamin C.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSIDE EFFECTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFollowing the use of Zerinolflu, the side effects indicated below may occur. The frequency of these side effects cannot be estimated from the available data. \u003cu\u003ePathologies of the blood and lymphatic system\u003c\/u\u003e: - thrombocytopenia, leukopenia, anemia, agranulocytosis, pancytopenia. \u003cu\u003eImmune system disorders\u003c\/u\u003e: - hypersensitivity reactions such as angioedema, laryngeal edema, anaphylactic shock. \u003cu\u003eNervous system disorders\u003c\/u\u003e: - drowsiness, asthenia, dizziness, headache, inability to concentrate. \u003cu\u003eEye pathologies\u003c\/u\u003e: - blurred vision. \u003cu\u003eRespiratory, thoracic and mediastinal disorders\u003c\/u\u003e: - thickening of bronchial secretions. \u003cu\u003eGastrointestinal disorders\u003c\/u\u003e: - dry mouth, nausea. \u003cu\u003eHepatobiliary disorders\u003c\/u\u003e: - alterations in liver function and hepatitis. \u003cu\u003ePathologies of the skin and subcutaneous tissue\u003c\/u\u003e: - skin reactions of various types and severity have been reported with the use of paracetamol including cases of urticaria, erythema multiforme, very rare cases of serious skin reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and acute generalized exanthematous pustulosis (AGEP). Photosensitization. \u003cu\u003eRenal and urinary disorders\u003c\/u\u003e: - renal alterations (acute renal failure, interstitial nephritis, haematuria, anuria), urinary retention. \u003cb\u003eReporting of suspected adverse reactions\u003c\/b\u003e Reporting suspected adverse reactions that occur after authorization of the medicine is important, as it allows continuous monitoring of the benefit\/risk balance of the medicine. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system at: www.agenziafarmaco.gov.it\/it\/responsabili.\u003c\/p\u003e","brand":"Zentiva","offers":[{"title":"Default Title","offer_id":51131278360903,"sku":"035191030","price":15.72,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0564\/4989\/2467\/files\/zentiva-italia-srl-zerinolflu-20-compresse-effervescenti-farmacia-dottor-tili-1213792255.jpg?v=1767133590","url":"https:\/\/www.dottortili.com\/en-eu\/products\/zerinolflu-20-effervescent-tablets","provider":"Farmacia Dottor Tili","version":"1.0","type":"link"}