{"product_id":"sodio-cloruro-salf-0-9-100-ml-soluzione-per-infusione","title":"Sodium chloride SALF 0.9% 100 ml solution for infusion","description":"\u003cp\u003e\u003cstrong\u003eINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFluid and sodium chloride replacement.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eACTIVE INGREDIENTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1000 ml contain: \u003ci\u003eActive ingredient:\u003c\/i\u003e sodium chloride 9 g mEq\/l: Na\u003csup\u003e+\u003c\/sup\u003e 154 mEq\/l: Cl\u003csup\u003e-\u003c\/sup\u003e 154 Theoretical osmolarity (mOsm\/l): 308 pH: 4.5 - 7.0 1 g of NaCl = 394 mg of Na\u003csup\u003e+\u003c\/sup\u003e or 17.1 mEq or 17.1 mmol Na\u003csup\u003e+\u003c\/sup\u003e and Cl\u003csup\u003e-\u003c\/sup\u003e 1 mmol Na\u003csup\u003e+\u003c\/sup\u003e = 23 mg of Na\u003csup\u003e+\u003c\/sup\u003e For the full list of excipients, see section 6.1.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEXCIPIENTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWater for injections.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS AND SIDE EFFECTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHypernatremia. Hydrosaline plethora.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDOSAGE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe medicine must be administered by intravenous infusion. \u003cb\u003e \u003ci\u003eTreatment of isotonic fluid depletion (extracellular dehydration) \u003c\/i\u003e \u003c\/b\u003e \u003cu\u003eAdults and adolescents\u003c\/u\u003e: from 500 ml to 3 liters in 24 hours. \u003cu\u003eInfants and children (up to 12 years of age)\u003c\/u\u003e: 20 to 100 ml per 24 hours and per kg of body weight, depending on age and total body weight. The dosage must be appropriately reduced in patients with renal insufficiency. \u003cb\u003e \u003ci\u003eTreatment of sodium deficiency\u003c\/i\u003e \u003c\/b\u003e The dose depends on age, weight, clinical conditions, electrolyte status and osmolarity, and is in relation to the calculated sodium deficit. The theoretical sodium deficit can be calculated using the following formula: DEFICIT (mEq) = (140 - P) x V P = plasma sodium concentration (in mEq\/l) V = body water volume (equal to 60% of body weight for children and adult males, 50% for adult women, 50% and 45% for men and elderly women respectively). In conditions of severe sodium depletion and in the treatment of severe symptoms related to chronic hyponatremia, administer hypertonic sodium chloride solutions in order to increase the plasma sodium concentration by 1-2 mmol\/l\/hour. Pay attention that the correction does not exceed 10-12 mmol\/l in 24 hours and 18 mmol\/l in 48 hours. In the event that sodium chloride solutions, and in particular 0.9% solutions, are used as diluting solutions for the intravenous administration of medicines that must be previously diluted, check beforehand the compatibility of these medicines with sodium chloride and its most suitable concentration for administration in the SmPC of the medicine to be diluted. If the concentration is not indicated, use the 0.9% solution.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONSERVATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStore in hermetically closed container. Do not freeze or refrigerate. The solution must be clear, colorless and free of visible particles.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWARNINGS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSodium salts should be administered with caution in patients with hypertension, heart failure, peripheral or pulmonary edema, reduced renal function, pre-eclampsia, or other conditions associated with sodium retention (see section 4.5). Use with great caution in patients with congestive heart failure, severe renal insufficiency and in clinical states where edema with salt retention exists; in patients being treated with corticosteroids or corticotropin drugs. Continuous administration without addition of potassium may cause hypokalemia. Use with caution in children. During the infusion it is good practice to monitor fluid balance, electrolytes, plasma osmolarity and acid-base balance. The solution must be clear, colorless and free of visible particles. Use immediately after opening the container. The container is used for a single, uninterrupted administration and any residue cannot be used.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eINTERACTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCorticosteroids are associated with sodium and water retention, resulting in edema and hypertension: therefore, caution should be used in the simultaneous administration of sodium salts and corticosteroids (see section 4.4). Although sodium chloride is compatible with a large number of solutions and medicines, it is advisable to check its compatibility in the SmPC of the medicine you intend to co-administer.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSIDE EFFECTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBelow are the side effects of sodium chloride, organized according to the MedDRA system organic classification. There is insufficient data to establish the frequency of the individual effects listed. \u003ci\u003eDisorders of water and electrolyte balance \u003c\/i\u003e Hypernatremia, hypervolemia, hyperchloremia (which can cause a loss of bicarbonates resulting in acidosis) \u003ci\u003eNervous system disorders \u003c\/i\u003e Headache, dizziness, restlessness, fever, irritability, weakness, muscle stiffness, seizures, coma, death \u003ci\u003ePsychiatric disorders \u003c\/i\u003e Drowsiness, confusional states \u003ci\u003eRespiratory, thoracic and mediastinal disorders \u003c\/i\u003e Dyspnea, respiratory arrest. \u003ci\u003eGastrointestinal disorders \u003c\/i\u003e Thirst, reduced salivation, nausea, vomiting, diarrhea, abdominal pain. \u003ci\u003eCardiac diseases \u003c\/i\u003e Tachycardia. \u003ci\u003eEye pathologies \u003c\/i\u003e Reduced tearing. \u003ci\u003eRenal and urinary disorders \u003c\/i\u003e Renal failure. \u003ci\u003eVascular pathologies \u003c\/i\u003e Hypotension, hypertension, pulmonary and peripheral edema. \u003ci\u003eSystemic pathologies and conditions relating to the administration site \u003c\/i\u003e Infection at the infusion site, local pain or reaction, venous irritation, venous thrombosis or phlebitis extending from the infusion site, extravasation.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOVERDOSE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSymptoms \u003c\/i\u003e The administration of excessive doses of isotonic and hypertonic sodium chloride solutions can lead, depending on the patient's clinical conditions, to hypernatremia, hyperchloremia and\/or hypervolemia. Hypernatremia (mainly associated with the administration of hypertonic solutions) and excessive sodium retention where there is a defective excretion of sodium at the renal level leads to dehydration of the internal organs, especially the brain, and the accumulation of extracellular fluids with edema which can affect the cerebral, pulmonary and peripheral circulation with the appearance of pulmonary and peripheral edema. The accumulation of chlorine ions causes a reduction in the concentration of bicarbonate ions, leading to acidosis. \u003ci\u003eTreatment \u003c\/i\u003e In case of accidental excessive infusion, the treatment must be suspended and the patient must be kept under observation to evaluate the appearance of any signs and symptoms related to the drug administered, guaranteeing the patient the relevant symptomatic and support measures as necessary. In case of overdose, therapy must be aimed at restoring physiological sodium ion concentrations. In these cases, intravenous administration of 5% glucose or hypotonic or isotonic sodium chloride solutions is recommended (as they are hypotonic for the hypernatremic patient). In case of high natremia, loop diuretics can be used. A blood sodium level above 200 mmol\/l may require the use of dialysis.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePREGNANCY AND BREASTFEEDING\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAlthough no effects on the development of the fetus have been highlighted, the medicine should be administered only in case of actual need and only after evaluating the risk\/benefit ratio with your doctor. The medicine is compatible with breastfeeding.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEFFECTS ON DRIVING ABILITY\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe medicine does not affect the ability to drive and use machinery.\u003c\/p\u003e","brand":"Salf","offers":[{"title":"Default Title","offer_id":51730213634375,"sku":"030684106","price":2.79,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0564\/4989\/2467\/files\/salf-sodio-cloruro-salf-0-9-100-ml-soluzione-per-infusione-farmacia-dottor-tili-1254211194.jpg?v=1786730066","url":"https:\/\/www.dottortili.com\/en-eu\/products\/sodium-chloride-salf-0-9-100-ml-solution-for-infusion","provider":"Farmacia Dottor Tili","version":"1.0","type":"link"}