{"product_id":"neo-nisidina-12-compresse","title":"Neo - Nisidine 12 tablets","description":"\u003cp\u003e\u003cstrong\u003eINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSymptomatic treatment of headaches, neuralgia, toothache, menstrual pain, joint pain, feverish states and cold syndromes.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eACTIVE INGREDIENTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1 tablet contains: active ingredients: acetylsalicylic acid 250 mg, paracetamol 200 mg, caffeine 25 mg. For excipients see section. 6.1\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEXCIPIENTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCorn starch, lactose, stearic acid.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS AND SIDE EFFECTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHypersensitivity to the active substance or to any of the excipients. Paracetamol-based products are contraindicated in patients with manifest glucose-6-phosphate dehydrogenase insufficiency and in those suffering from severe hemolytic anemia. Severe hepatocellular insufficiency. Neo-Nisidine should not be used in cases of active gastric or duodenal ulcers, in patients with an established tendency to bleeding (e.g. haemophilia) or who have hypersensitivity to salicylates or paracetamol or to other components of the product. Asthma patients. Dose \u003e 100 mg\/day of acetylsalicylic acid during the third trimester of pregnancy. The use of this medicine is contraindicated in children and adolescents under the age of sixteen. However, due to the risk of Reye's syndrome, Neo-Nisidine should not be used in children and adolescents affected by chickenpox or flu. Due to the presence of caffeine, do not administer to children and young people under the age of sixteen.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDOSAGE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eAdults:\u003c\/i\u003e 1 to 4 tablets per day. Oral intake must take place on a full stomach. Do not exceed the recommended doses, especially elderly patients should stick to the minimum dosages indicated above.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONSERVATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNone.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWARNINGS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis medicinal specialty must not be used in children and young people under the age of sixteen (see contraindications); subjects over 70 years of age, especially in the presence of concomitant therapies, should use this medicine only after consulting a doctor. After three days of use at the maximum dose or after 5-7 days of continuous use without results, consult your doctor. If pain or fever persists or worsens, if new symptoms appear or if there is redness or swelling, you should consult a doctor because these could be signs of a worsening of the current pathology. Administer with caution in subjects with renal or hepatic insufficiency. During treatment with paracetamol, before taking any other medicine, check that it does not contain the same active ingredient, since if paracetamol is taken in high doses, serious adverse reactions may occur. Furthermore, before combining any other medicine, contact your doctor. See also the entry “Interactions”. Furthermore, patients with glucose-6-phosphate dehydrogenase deficiency, chronic or recurrent gastric or intestinal disorders, or impaired renal function, asthma, allergic rhinitis and nasal polyps, hypersensitivity to non-steroidal anti-inflammatory drugs, liver dysfunction (e.g. due to chronic alcohol abuse, hepatitis), Gilbert's syndrome, pregnant women should consult their doctor. High or prolonged doses of the product can cause high-risk liver disease and even serious alterations to the kidney and blood. In case of viral diseases, such as flu or chickenpox, consult your doctor before administering the product to children; if prolonged vomiting and profound drowsiness appear during treatment, discontinue administration. The use of the product is not recommended if the patient is being treated with other anti-inflammatories. In rare cases of allergic reactions, administration must be suspended. Medicine containing lactose is therefore not suitable for subjects with lactase deficiency, galactosemia or glucose\/galactose malabsorption syndrome. Keep the medicine out of the reach and sight of children.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eINTERACTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe drug may interact with anticoagulants, uricosurics, hypoglycemic sulphonylureas. Pre-operative use may hinder intraoperative haemostasis. Acetylsalicylic acid, one of the components of Neo-Nisidina, can enhance the effect of anticoagulants (e.g. coumarin and heparin derivatives). It may also increase the risk of gastrointestinal side effects when administered simultaneously with nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids. The effect of hypoglycemic agents and the toxicity of methotrexate may be increased by concomitant administration of acetylsalicylic acid. Neo-Nisidine may decrease the natriuretic effect of spironolactone and inhibit the effect of uricosuric agents (e.g. probenecid, sulfinpyrazone). Patients being treated with rifampicin, cimetidine, or with antiepileptic drugs such as glutetimide, phenobarbital, carbamazepine must use paracetamol with extreme caution and only under close medical supervision. The administration of paracetamol can interfere with the determination of uric acid (using the phosphotungstic acid method) and with that of blood sugar (using the glucose-oxidase-peroxidase method). Drugs that slow gastric emptying, such as propantheline, reduce the speed of absorption of paracetamol and delay the onset of its effect. However, drugs that accelerate gastric emptying, such as metoclopramide, lead to an increase in the speed of absorption. The association of paracetamol with chloramphenicol can prolong the half-life of chloramphenicol, increasing the risk of toxicity. It was not possible to evaluate the clinical relevance of the interactions between paracetamol and warfarin and with coumarin derivatives. Therefore, prolonged use of paracetamol in patients being treated with oral anticoagulants is advisable only under medical supervision. The concomitant use of paracetamol and AZT (zidovudine) increases the risk of neutropenia induced by the latter. Therefore, Neo-Nisidine should be taken together with AZT only under medical supervision. Caffeine can antagonize the sedative effect of various drugs (e.g. barbiturates, antihistamines). It may also increase the tachycardia effect caused by other medicinal products (e.g. sympathomimetics, thyroxine). Oral contraceptives, cimetidine and disulfiram, slow down the metabolism of caffeine in the liver, barbiturates and smoking increase it. Caffeine reduces theophylline excretion. Concomitant administration of analgesics does not increase the risk of developing dependence. The administration of quinolone antibiotics may delay the elimination of caffeine.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSIDE EFFECTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSee also section 4.9. Acetylsalicylic acid can cause epigastric discomfort, nausea, vomiting, gastroduodenal ulcers and erosive gastritis which can lead to serious gastrointestinal bleeding. Such effects are more likely related to high doses although they may also occur at low doses. When using products containing acetylsalicylic acid for prolonged periods, iron deficiency anemia may occur due to recurring bleeding in the digestive tract. Due to the presence of acetylsalicylic acid, otovestibular disorders (humming, etc.), dizziness, hemorrhagic phenomena (epistaxis, gingivorrhagia, etc.), prolongation of pregnancy and labor and reduction in platelet count may also occur. Occasionally, allergic reactions may occur (bronchoconstriction, skin reactions). Skin reactions of various types and severity have been reported with the use of paracetamol, including rare cases of allergic skin rashes and cases of erythema multiforme, Stevens-Johnson syndrome and epidermal necrolysis. Hypersensitivity reactions such as angioedema, laryngeal edema, anaphylactic shock have been reported. Furthermore, the following side effects have been reported: thrombocytopenia, leukopenia, anemia, agranulocytosis, pancytopenia, alterations in liver function and hepatitis, alterations affecting the kidney (acute renal failure, interstitial nephritis, hematuria, anuria), gastrointestinal reactions and dizziness. In cases of overdosage, due to the presence of paracetamol, hepatic cytolysis can be caused, which can evolve towards massive and irreversible necrosis. Caffeine is a CNS stimulant and can cause agitation, insomnia, tremor, dyspeptic symptoms, and tachycardia. Due to the presence of caffeine, in case of overdose, a hyperstimulation syndrome may occur with excitation, insomnia, buzzing, muscle tremor, nausea, vomiting, increased diuresis, tachycardia, extrasystole, scotoma.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOVERDOSE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSymptoms\u003c\/i\u003e: The ingestion of excessive doses of paracetamol can cause signs of toxicity identifiable in liver dysfunction due to necrosis of liver cells up to hepatic coma after 24-48 hours, even with fatal outcome. Independently of these phenomena, renal lesions due to tubular necrosis have also been described. The symptoms of paracetamol poisoning manifest themselves in different stages. In the first phase (1st day) the signs are nausea, vomiting, sweating, drowsiness and a general feeling of malaise. After a temporary subjective improvement, in the second phase (the third or fourth day) a considerable increase in transaminase values, jaundice, coagulation disorders, hypoglycemia with possible transition to hepatic coma tend to appear. Symptoms of moderate to acute toxicity of acetylsalicylic acid are: hyperventilation, tinnitus, nausea, vomiting, impaired vision and hearing, dizziness and confusion. In case of severe poisoning, delirium, tremor, convulsions, dyspnea, sweating, bleeding, dehydration, disturbances of the acid-base balance and electrolyte composition of the plasma, hyperthermia and coma may be observed. The first symptoms of an acute caffeine overdose are normally tremor and agitation. These are followed by nausea, vomiting, tachycardia and confusion. Symptoms caused by severe intoxication can be delirium, seizures, supraventricular and ventricular tachycardia, hypokalemia and hyperglycemia. \u003ci\u003eTherapy\u003c\/i\u003e: Treatment should begin with usual therapies (e.g. activated charcoal, gastric lavage). Treatment of acetylsalicylic acid overdose mainly consists of measures to increase its elimination through forced alkaline diuresis and to re-establish acid-base and electrolyte balance. Infusions of sodium bicarbonate and potassium chloride solutions may be administered. The cytotoxic metabolite of paracetamol can be neutralized if possible in the first 8-12 hours after intoxication through intravenous administration of SH group donor drugs, such as acetylcysteine ​​which should be used at the first symptoms of intoxication. Serial testing of paracetamol plasma concentration and liver function is recommended. The plasma concentration of both acetylsalicylic acid and paracetamol can be reduced by dialysis.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePREGNANCY AND BREASTFEEDING\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003ePregnancy\u003c\/i\u003e: Low doses of acetylsalicylic acid (up to 100 mg\/day): Clinical studies indicate that doses up to 100 mg\/day can be considered safe limited to use in obstetrics, which requires specialist monitoring. Doses of 100-500 mg\/day of acetylsalicylic acid: There are insufficient clinical data relating to the use of doses higher than 100 mg\/day up to 500 mg\/day. Therefore, the recommendations below for doses of 500 mg\/day and above also apply to this dosage range. Doses of 500 mg\/day and more of acetylsalicylic acid: The inhibition of prostaglandin synthesis can negatively affect pregnancy and\/or embryo\/foetal development. Results of epidemiological studies suggest an increased risk of miscarriage and cardiac malformation and gastroschisis after the use of a prostaglandin synthesis inhibitor in the early stages of pregnancy. The absolute risk of cardiac malformations was increased from less than 1% to approximately 1.5%. It has been estimated that the risk increases with the dose and duration of therapy. In animals, the administration of prostaglandin synthesis inhibitors has been shown to cause an increase in pre- and post-implantation loss and embryo-foetal mortality. Furthermore, an increased incidence of various malformations, including cardiovascular malformations, has been reported in animals to which prostaglandin synthesis inhibitors were administered during the organogenetic period. During the first and second trimester of pregnancy, acetylsalicylic acid should not be administered unless strictly necessary. If acetylsalicylic acid is used by a woman attempting to conceive, or during the first and second trimester of pregnancy, the dose and duration of treatment should be kept as low as possible. During the third trimester of pregnancy, all inhibitors of prostaglandin synthesis can expose the fetus to: cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension); renal dysfunction, which may progress to renal failure with oligo-hydramnios; the mother and newborn, at the end of pregnancy, to: possible prolongation of bleeding time, and anti-aggregating effect which can occur even at very low doses; inhibition of uterine contractions resulting in delay or prolongation of labour. Consequently, acetylsalicylic acid at doses \u003e 100 mg\/day is contraindicated during the third trimester of pregnancy. Prolonged intake of high amounts of caffeine can induce miscarriage or premature birth. \u003ci\u003eBreastfeeding\u003c\/i\u003e: Paracetamol and salicylates are excreted in breast milk. Caffeine is also excreted in breast milk and can influence the state and behavior of the baby. If, during breastfeeding, regular therapy with higher doses of acetylsalicylic acid is necessary, weaning should be considered.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEFFECTS ON DRIVING ABILITY\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product does not interfere with the ability to drive vehicles and use machinery.\u003c\/p\u003e","brand":"Pharmaidea","offers":[{"title":"Default Title","offer_id":51730206425415,"sku":"004558185","price":6.4,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0564\/4989\/2467\/files\/pharmaidea-srl-neo-nisidina-12-compresse-farmacia-dottor-tili-1213791107.jpg?v=1767140069","url":"https:\/\/www.dottortili.com\/en-eu\/products\/neo-nisidine-12-tablets","provider":"Farmacia Dottor Tili","version":"1.0","type":"link"}